CAS Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency with continuous positive airway pressure delivered by a face mask: A randomized controlled trial. Demoule, A. et al. Health officials: Ventilator mortality rate high because of severity of 46, 854887 (2020). Outcome of COVID-19 patients with haematological malignancies after the Crit. AHCFD is comprised of 9 hospitals with a total of 2885 beds servicing the 8 million residents of Orange County and surrounding regions. ICU specific management and interventions including experimental therapies and hospital as well as ICU length of stay (LOS) are described in Table 3. Patient characteristics and clinical outcomes were compared by survival status of COVID-19 positive patients. These data are complementary and still useful later on by including some patients usually excluded from randomized studies; patients with do-not-intubate orders are an example and, obviously, they represent a challenge for the physician responsible to decide the best therapeutic strategy. Neil Finkler Of these patients who were discharged, 60 (45.8%) went home, 32 (24.4%) were discharged to skill nurse facilities and 2 (1.5%) were discharged to other hospitals. Respiratory Department. Trends in survival during the pandemic in patients with critical COVID At age 53 with Type 2 diabetes and a few extra pounds, my chance of survival was far less than 50 percent. After adjustment, and taking patients treated with HFNC as reference, patients who underwent NIV had a higher risk of intubation or death at 28days (HR 2.01, 95% CI 1.323.08), while those treated with CPAP did not present differences (HR 0.97, 95% CI 0.631.50) (Table 4). Lower positive end expiratory pressure (PEEP) were observed in survivors [9.2 (7.710.4)] vs non-survivors [10 (9.112.9] p = 0.004]. Richard Pratley, Among them, 22 (30%) died within 28days (5/36 in HFNC (14%), 5/14 in CPAP (36%), and 12/23 in NIV (52%) groups, p=0.007). Vitacca, M., Nava, S., Santus, P. & Harari, S. Early consensus management for non-ICU acute respiratory failure SARS-CoV-2 emergency in Italy: From ward to trenches. Article A covid-19 patient is attached to a ventilator in the emergency room at St. Joseph's Hospital in Yonkers, N.Y., in April. The patients who had died by day 28 were 117 (31.9%), 91 (65%) of those patients were treated with NIRS as ceiling of treatment and 26 (11.5%) were treated with NIRS not regarded as ceiling of treatment. Support COVID-19 research at Mayo Clinic. Am. High-flow nasal cannula in critically III patients with severe COVID-19. All critical care admissions from March 11 to May 18, 2020 presenting to any one of the 9 AHCFD hospitals were included. The effects also could lead to the development of new conditions, such as diabetes or a heart or nervous . Obviously, reaching a definitive conclusion on this point will require further studies with better phenotypic characterization of patients, and considering additional factors implicated in the response to therapies such as the interface used or the monitoring of the inspiratory effort. What Are the Chances a Hospitalized Patient Will Survive In-Hospital In total, 139 of 372 patients (37%) died. 4h ago. Of these 9 patients, 8 were treated with veno-venous ECMO (survival 7 of 8) and one with veno-arterial-venous ECMO (survival 1 of 1). Regional experiences in the management of critically ill patients with severe COVID-19 have varied between cities and countries, and recent reports suggest a lower mortality rate [10]. Hypertension was the most common co-morbid condition (84 pts, 64%), followed by diabetes (54, 41%) and coronary artery disease (21, 16%). Among the patients with COVID-19 CAP, mortalities, mechanical ventilators, ICU admissions, ICU stay, and hospital costs . Tocilizumab was utilized in 56 (43.7%), and 37 (28.2%) were enrolled in blinded placebo-controlled studies aimed at the inflammatory cascade. As for secondary outcomes, patients treated with NIV had a significantly higher risk of endotracheal intubation, 28-day mortality, and in-hospital mortality than patients treated with HFNC, while no differences were observed between CPAP and HFNC (Fig. Division of Critical Care AdventHealth Medical Group, AdventHealth Orlando, Orlando, Florida, United States of America, Affiliation: Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study, Early extubation with immediate non-invasive ventilation versus standard weaning in intubated patients for coronavirus disease 2019: a retrospective multicenter study, Patient characteristics and outcomes associated with adherence to the low PEEP/FIO2 table for acute respiratory distress syndrome. Respir. N. Engl. Copy link. Drafting of the manuscript: S.M., A.-E.C. Days between NIRS initiation and intubation (median (P25-P75) 3 (15), 3.5 (27), and 3 (35), for HFNC, CPAP, and NIV groups respectively; p=0.341) and the length of hospital stay did not differ between groups (Table 4). As a result, a considerable proportion of severe patients are being treated in hospital settings outside the ICU. The requirement of informed consent was waived due to the retrospective nature of the study. Opin. Emerging data suggest that patients with comorbidities are less likely to survive intensive care unit (ICU) admission for severe COVID-19. A multicentre, retrospective cohort study of COVID-19 patients followed from NIRS initiation up to 28days or death, whichever occurred first. Out of total of 1283 patients with COVID-19, 131 (10.2%) met criteria for ICU admission (median age: 61 years [interquartile range (IQR), 49.571.5]; 35.1% female). Cardiac arrest survival rates. 56, 2001692 (2020). 50, 1602426 (2017). This alone may explain some of our lower mortality [35]. Grasselli, G., Pesenti, A. Annalisa Boscolo, Laura Pasin, FERS, for the COVID-19 VENETO ICU Network, Gianmaria Cammarota, Rosanna Vaschetto, Paolo Navalesi, Kay Choong See, Juliet Sahagun & Juvel Taculod, Ayham Daher, Paul Balfanz, Christian G. Cornelissen, Ser Hon Puah, Barnaby Edward Young, Singapore 2019 novel coronavirus outbreak research team, Denio A. Ridjab, Ignatius Ivan, Dafsah A. Juzar, Ana Catarina Ishigami, Jucille Meneses, Vineet Bhandari, Jess Villar, Jess M. Gonzlez-Martin, Arthur S. Slutsky, Scientific Reports Mechanical ventilation to minimize progression of lung injury in acute respiratory failure. Yoshida, T., Grieco, D. L., Brochard, L. & Fujino, Y. Mortality in Patients With Severe COVID-19 Pneumonia Who Underwent 95, 103208 (2019). Stata Statistical Software: Release 16. Although treatment received and outcomes differed by hospital, this fact was taken into account through adjustment. A sample is collected using a swab of your nose, your nose and throat, or your saliva. All participating hospitals belong to the National Health System of Catalonia, Spain, and attend a population of around 4.3 million inhabitants. Nevertheless, we do not think it may have influenced our results, because analyses were adjusted for relevant treatments such as systemic corticosteroids40 and included the time period as a covariate. Long-term survival of mechanically ventilated patients with severe Median Driving pressure were similar between the two groups (12.7 [10.815.1)]. Mauri, T. et al. Between April 2020 and May 2021, 1,273 adults with COVID-19-related acute hypoxemic respiratory failure were randomized to receive NIV (n = 380), HFNC oxygen (n = 418), or conventional oxygen therapy (n = 475). Also, of note, 37.4% of our study population received convalescent plasma, and larger studies are underway to understand its role in the treatment of severe COVID-19 [14, 32]. No follow-up after discharge was performed and if a patient was re-admitted to another facility after discharge, the authors would not know. Outcomes by hospital are listed in Table S4. On average about 98.2% of known COVID-19 patients in the U.S. survive, but each individual's chance of dying from the virus will vary depending on their age, whether they have an underlying . & Kress, J. P. Effect of noninvasive ventilation delivered helmet vs. face mask on the rate of endotracheal intubation in patients with acute respiratory distress syndrome: A randomized clinical trial. Clinical severity and laboratory values were well balanced between the groups (Table 2 and Table S2), except for respiratory rate (higher in patients treated with NIV). Copyright: 2021 Oliveira et al. Given the small number of missing information and that missing were considered at random, we conducted a complete case approach. 3 COVID-19 Survivors on the Brink of Death Who Lived Against - Insider Midterms 2022; UK; Europe; . The unadjusted 30-day mortality of people with COVID-19 requiring critical care peaked in March 2020 with an HDU mortality of 28.4% and ICU mortality of 42.0%. Sensitivity analyses included: (1) repeating models excluding patients who changed their initial NIRS treatment during the course of the hospitalization to another NIRS treatment (crossover, n=44); (2) excluding patients with missing measured PaO2/FIO2 (n=123); (3) excluding patients receiving NIRS as ceiling of treatment (n=140); and (4) additionally adjusting models for, one at a time, D-dimer levels, respiratory rate, systemic corticosteroid use and Charlson index. 195, 6777 (2017). Clinical consensus recommendations regarding non-invasive respiratory support in the adult patient with acute respiratory failure secondary to SARS-CoV-2 infection. Our study was carried out during the first wave of the pandemics when the healthcare system was overwhelmed and many patients were treated outside ICU facilities. Tobin, M. J., Jubran, A. 44, 439445 (2020). However, the retrospective design of our study does not allow establishing a causative link between NIV and the worse clinical outcomes observed. As noted above, a single randomized study has evaluated helmet NIV against HFNC in COVID-1919, and, in spite of the lower intubation rate in the helmet NIV group, no differences in 28-day mortality were registered. Although our study was not designed to assess the effectiveness of any of the above medications, no significant differences between survivors and non-survivors were observed through bivariate analysis. This study was approved by the institutional review board of AHCFD, which waived the requirement for individual patient consent for participation. MiNK Therapeutics Announces 77% Survival Rate in Intubated Patients with COVID-19 Respiratory Failure Treated with AgenT-797 PRESS RELEASE GlobeNewswire Nov. 12, 2021, 07:00 AM Of the total amount of patients admitted to ICU (N = 131), 80.2% (N = 105) remained alive at the end of the study period. Intubation was performed when clinically indicated based on the judgment of the responsible physician. Long-term Outcomes in Critically Ill Patients With COVID-19 in the Moreover, NIRS treatment groups exhibited only minor differences which were accounted for in the multivariable and sensitivity analyses thus minimizing the selection bias risk. Nursing did not exceed ratios of one nurse to two patients. Recommended approaches to minimize aerosol dispersion of SARS-CoV-2 during noninvasive ventilatory support can cause ventilator performance deterioration: A benchmark comparative study. During the study period, 26 patients of the total (N = 131) expired (19.8% overall mortality). Coronavirus disease 2019 (COVID-19) has affected over 7 million of people around the world since December 2019 and in the United States has resulted so far in more than 100,000 deaths [1]. A total of 14 (10.7%) received remdesivir via expanded access or compassionate use programs, as well as through the Emergency Use Authorization (EUA) supply distributed by the Florida Department of Health. Up to 1015% of hospitalized cases with coronavirus disease 2019 (COVID-19) are in critical condition (i.e., severe pneumonia and hypoxemic acute respiratory failure, HARF), have received invasive mechanical ventilation, and are admitted to the intensive care unit (ICU)1,2. The 30 ml/kg crystalloid resuscitation recommendation was applied for those patients presenting with evidence of septic shock and fluid resuscitation was closely monitored to minimize overhydration [18]. Prone Positioning techniques were consistent with the PROSEVA trial recommendations [17]. https://doi.org/10.1038/s41598-022-10475-7, DOI: https://doi.org/10.1038/s41598-022-10475-7. But after 11 days in the intensive care unit, and thanks to the tireless care of. Google Scholar. Hospital, Universitari Vall dHebron, Passeig Vall dHebron, 119-129, 08035, Barcelona, Spain, Sergi Marti,Jlia Sampol,Mercedes Pallero,Eduardo Vlez-Segovia&Jaume Ferrer, Universitat Autnoma de Barcelona (UAB), Barcelona, Spain, CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain, Sergi Marti,Jlia Sampol,Mercedes Pallero,Manel Lujan,Cristina Lalmolda,Juana Martinez-Llorens&Jaume Ferrer, Anne-Elie Carsin,Susana Mendez&Judith Garcia-Aymerich, Universitat Pompeu Fabra (UPF), Barcelona, Spain, Anne-Elie Carsin,Juana Martinez-Llorens&Judith Garcia-Aymerich, CIBER Epidemiologa y Salud Pblica (CIBERESP), Madrid, Spain, Respiratory Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, Respiratory Department, Corporaci Sanitria Parc Tauli, Sabadell, Spain, Manel Lujan,Cristina Lalmolda&Elena Prina, Department of Pulmonology, Dr. Josep Trueta, University Hospital of Girona, Santa Caterina Hospital of Salt, Girona, Spain, Gladis Sabater,Marc Bonnin-Vilaplana&Saioa Eizaguirre, Girona Biomedical Research Institute (IDIBGI), Girona, Spain, Respiratory Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, Respiratory Department, Hospital del Mar, Barcelona, Spain, Juana Martinez-Llorens&Ana Bala-Corber, Respiratory Department, Hospital General de Granollers, Granollers, Spain, Universitat Internacional de Catalunya, Barcelona, Spain, Respiratory Department, Althaia Xarxa Assistencial Universitria de Manresa, Manresa, Spain, Respiratory Department, Hospital Universitari de Bellvitge, LHospitalet de Llobregat, Llobregat, Spain, Respiratory Department, Hospital Mtua de Terrassa, Terrassa, Spain, You can also search for this author in Care 59, 113120 (2014). In fact, our mortality rates for mechanically ventilated COVID-19 patients were similar to APACHE IVB predicted mortality, which was based on critically ill patients admitted with respiratory failure secondary to viral and/or bacterial pneumonia. In addition, 26 patients who presented early intolerance were treated subsequently with other NIRS treatment, and were included as study patients in this second treatment: 8 patients with intolerance to HFNC (2 patients treated subsequently with CPAP, and 6 with NIV), 11 patients with intolerance to CPAP (5 treated later with HFNC, and 6 with NIV), and 7 patients with intolerance to NIV (5 treated after with HFNC, and 2 with CPAP). Our observational study is so far the first and largest in the state of Florida to describe the demographics, baseline characteristics, medical management and clinical outcomes observed in patients with CARDS admitted to ICU in a multihospital health care system. Dexamethasone in hospitalized patients with Covid-19. Thus, we believe that our results may be useful for a great number of physicians treating COVID-19 patients around the world. 10 A person can develop symptoms between 2 to 14 days after contact with the virus. Cardiac arrest survival rates Email 12/22/2022-Handy. "In severe cases, it can lead to a life threatening condition called acute respiratory distress syndrome." Healthline reported that ventilators can be lifesaving for people with severe respiratory symptoms, and that toughly 2.5% of people with COVID-19 will need a mechanical ventilator. Fourth, it could be argued that changes in treatment strategies over the timeframe of the study may have led to differential effects of the NIRS. Maria Carrilo, 57, 2002524 (2021). The main strength of this study is, in our opinion, its real-life design that allows obtaining the effectiveness of these techniques in the clinical setting. When and Why You Need a Ventilator During COVID-19 Pandemic Fourth, non-responders to NIV could have suffered a delay in intubation, but in our study the time to intubation was similar in the three NIRS groups, thus making this explanation less likely. However, as more home devices were used in the CPAP group (81.6% vs. 38% in the NIV group; Table S3), and better outcomes were recorded in the CPAP-treated patients, our result do not support this concern. Respir. At the initiation of NIRS, patients had moderate to severe hypoxemia (median PaO2/FIO2 125.5mm Hg, P25-P75: 81174). It's calculated by dividing the number of deaths from the disease by the total population. Failure of noninvasive ventilation for de novo acute hypoxemic respiratory failure: Role of tidal volume. Although the effectiveness and safety of this regimen has been recently questioned [12]. Google Scholar. In the stratified analysis of our cohort, planned a priori, patients with a PaO2/FIO2 ratio above 150 responded similarly to HFNC and NIV treatments, suggesting that the severity of the hypoxemia might predict the success of NIV, as previously reported in non-COVID patients4,28,29. The researchers found that at age 20, an individual with COVID-19 had a 4.27 times higher chance of dying from the infection than any other 20 year old in China has a of dying from any cause.. By submitting a comment you agree to abide by our Terms and Community Guidelines. Sci. Keep reading as we explain how. High-flow nasal cannula oxygen therapy to treat patients with hypoxemic acute respiratory failure consequent to SARS-CoV-2 infection. (2021) ICU outcomes and survival in patients with severe COVID-19 in the largest health care system in central Florida. Brown, S. M. et al. Patients with haematological malignancies (HM) and SARS-CoV-2 infection present a higher risk of severe COVID-19 and mortality. . Baseline demographic characteristics of the patients admitted to ICU with COVID-19. Lack of Progress in Treating Covid Causes Worry for Unvaccinated Brusasco, C. et al. Statistical significance was set at P<0.05. Docherty, A. Among the other 26 patients who had CKD, 9 of 19 patients (47%) with end-stage renal failure (ESRF), who . Am. With an expected frequency of 50% for intubation or death in patients with HARF and treated by NIRS28, 300 patients were needed in order to detect a significant difference greater than 20% between the types of NIRS evaluated in the present study, with an alpha risk of 0.05 and a statistical power of 80%. Survival After In-Hospital Cardiac Arrest in Critically Ill Patients Am. First, NIV has been reported to produce overdistension, compounded by the respiratory effort itself30, which could result in ventilation-induced lung injury due to the excessive increases in tidal volumes28,31. A relative COVID-19 survival analysis - News-Medical.net e0249038. The life-support system called ECMO can rescue COVID-19 patients from the brink of death, but not at the rates seen early in the pandemic, a new international study finds. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. The dose and duration of steroids were based on the study by Villar J. et al, that showed an improvement in survival in patients with ARDS after using dexamethasone [33, 34]. College Station, TX: StataCorp LLC. In addition to NIRS treatment, conscious pronation was performed in some patients. When COVID-19 leads to ARDS, a ventilator is needed to help the patient breathe. Most of these patients admitted to ICU, will finally require invasive mechanical ventilation (MV) due to diffuse lung injury and acute respiratory distress syndrome (ARDS). Based on recent reports showing hypercoagulable state and increased risk of thrombosis in patients with COVID-19, deep vein thrombosis (DVT) prophylaxis was initiated by following an institutional algorithm that employed D-dimer levels and rotational thromboelastometry (ROTEM) to determine the risk of thrombosis [19]. Sonja Andersen, Compared to non-survivors, survivors had a longer MV length of stay (LOS) [14 (IQR 822) vs 8.5 (IQR 510.8) p< 0.001], Hospital LOS [21 (IQR 1331) vs 10 (71) p< 0.001] and ICU LOS [14 (IQR 724) vs 9.5 (IQR 611), p < 0.001]. Our study does not support the previously reported overwhelmingly poor outcomes of mechanically ventilated patients with COVID-19 induced respiratory failure and ARDS. Aliberti, S. et al. Outcomes of COVID-19 patients intubated after failure of non - Nature ECMO life support offers sickest COVID-19 patients a chance to survive 44, 282290 (2016). JAMA 327, 546558 (2022). This secondary analysis of an ongoing adaptive platform trial examines the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes. [Accessed 25 Feb 2020]. B. Of the 1511 inpatients with CAP, COVID-19 was the leading cause, accounting for 27%. Luis Mercado, Competing interests: The authors have declared that no competing interests exist. Patel, B. K., Wolfe, K. S., Pohlman, A. S., Hall, J. How Covid survival rates have improved . Patients with both COPD and COVID-19 commonly experience dyspnea, or shortness of breath. 'Bridge to nowhere': People placed on ventilators have high chance of mortality The chance of mortality dramatically increases upwards to 50% when respiratory compromised patients are placed. Expert consensus statements for the management of COVID-19-related acute respiratory failure using Delphi method. This was consistent with care in other institutions. National Health System (NHS). Potential benefit has been described for remdesivir in reducing the duration of hospital LOS, but it has not been shown to improve patient survival, especially in the critically ill population [11]. Ventilators can be lifesaving for people with severe respiratory symptoms. Transfers between system hospitals were considered a single visit. Differences were also found in the NIRS treatments applied according to the date of admission: HFNC was the most frequent treatment early in the period (before 23 March), while CPAP was the most frequent choice in the second and the third periods (Table 1, p=0.008). The regional and institutional variations in ICU outcomes and overall mortality are not clearly understood yet and are not related to the use experimental therapies, given the fact that recent reports with the use remdesivir [11], hydroxychloroquine/azithromycin [12], lopinavir-ritonavir [13] and convalescent plasma [14, 15] have been inconsistent in terms of mortality reduction and improvement of ICU outcomes. The decision to intubate was left to physician judgement, which may restrict the generalizability of our results to institutions with stricter criteria for mechanical ventilation. The REDCap consortium: Building an international community of software platform partners. All analyses were performed using StataCorp. During March 11 to May 18, a total of 1283 COVID-19 positive patients were evaluated in the Emergency Department or ambulatory care centers of AHCFD. N. Engl. In the early months of the pandemic especially, the survival rate for intubated Covid patients was about 50 percent, and that included people who were younger and healthier than Mr.. JAMA 315, 801810 (2016). The 12 coronavirus patients who were put on ventilator support at the Government Rajindra Hospital in Patiala ended up succumbing to the disease. Background: Invasive mechanical ventilation (IMV) in COVID-19 patients has been associated with a high mortality rate. Eur. Of those alive patients, 88.6% (N = 93) were discharged from the hospital. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. Article Rubio, O. et al. The truth is that 86% of adult COVID-19 patients are ages 18-64, so it's affecting many in our community. All analyses were performed using version 3.6.3 of the R programming language (R Project for Statistical Computing; R Foundation). Autopsy studies of patients who died of severe SARS CoV-2 infection reveal presence of . Crit. For initial laboratory testing and clinical studies for which not all patients had values, percentages of total patients with completed tests are shown. B. et al. Membership of the author group is listed in the Acknowledgments. Our study demonstrates an important improvement in mortality of patients with severe COVID-19 who required ICU admission and MV in comparison to previous observational reports and emphasizes the importance of standard of care measures in the management of COVID-19. PubMed Retrospective cohort study of patients admitted to ICU due to severe COVID-19 in AdventHealth health system in Orlando, Florida from March 11th until May 18th, 2020. Bellani, G. et al. The sample is then checked for the virus's genetic material (PCR test) or for specific viral proteins (antigen test). Internet Explorer). Full anticoagulation was given to 48 (N = 131, 36.6%) of the patients and 77 (N = 131, 58.8%) received high dose corticosteroids (methylprednisolone 40mg every 8 hours for 7 days or dexamethasone 20 mg every day for 5 days followed by 10 mg every day for 5 days). COVID-19 Hospital Data - In-hospital mortality among confirmed COVID-19 The mortality rate among 165 COVID-19 patients placed on a ventilator at Emory was just under 30%. Patients were also enrolled in institutional review board (IRB) approved studies for convalescent plasma and other COVID-19 investigational treatments. Severe covid-19 pneumonia: pathogenesis and clinical management Share this post. Those patients requiring mechanical ventilation were supervised by board-certified critical care physicians (intensivists). High-flow oxygen administered via nasal cannula, Arterial partial pressure of carbon dioxide, Quick sequential organ failure assessment. 56, 2001935 (2020). Intensiva (Engl Ed). A total of 73 patients (20%) were intubated during the hospitalization. Mortality Risk of COVID-19 - Our World in Data Inform. Surviving sepsis campaign: Guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19). Jason Price, R.N., Sanjay Pattani, M.D., Brett Spenst, M.B.A., Amanda Tarkowski, M.D., Fahd Ali, M.D., Otsanya Ochogbu, PharmD., Bassel Raad, M.D., Mohammad Hmadeh, M.D., Mehul Patel, M.D. After adjusting for relevant covariates and taking patients treated with HFNC as reference, treatment with NIV showed a higher risk of intubation or death (hazard ratio 2.01; 95% confidence interval 1.323.08), while treatment with CPAP did not show differences (0.97; 0.631.50). Victor Herrera, 195, 438442 (2017). Harris, P. A. et al. ICU outcomes at the end of study period are described in Table 4. Rep. 11, 144407 (2021). [view Recently, the effectiveness of CPAP or HFNC compared with conventional oxygen therapy was assessed in the RECOVERY-RS multicentric randomized clinical trial, in 1,273 COVID-19 patients with HARF who were deemed suitable for tracheal intubation if treatment escalation was required20.
Una Nilsson Age, Five Year Engagement Filming Locations San Francisco, Dixie State University Application Deadline Spring 2022, Who Did Emma Sophocleous Play In Eastenders, Where To Live In Peterborough, Articles S